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The immune system is organized so as to react to pathogens without risking damage to self. Harnessing those processes that prevent self-reactivity will have enormous potential in clinical medicine. This review outlines the efforts of this laboratory over the last 25 years to exploit tolerance so as to reprogram the immune system for therapeutic purposes.


Journal article


Immunol Rev

Publication Date





227 - 235


Allergy and Immunology, Animals, Graft Rejection, Graft Survival, History, 20th Century, Humans, Immune System, Immune Tolerance, Models, Immunological