Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

CD8(+) T cell clones secrete soluble factor(s), generally referred to as T cell-derived anti-viral factors (CAFs) that inhibit HIV replication in vitro. The CAF-like activity of some of the clones we are studying is inducible by anti-CD8 antibody. The CD8 antibody-inducibility of one such clone, clone 32, has allowed us to focus, in principle, on CAF-encoding genes using the serial analysis of gene expression (SAGE) method. Using this approach, a complex pattern of transcriptional changes was found to accompany antibody treatment, with skewed expression of certain effector molecules. Our transcriptome-based approach provides the first overview of the transcriptional properties of a CD8(+) T cell with CAF-like activity, and places new constraints on strategies for identifying CAF-like factors.


Conference paper

Publication Date



131 - 135