Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Mutations in human immunodeficiency virus (HIV) cluster in cytotoxic T lymphocyte (CTL) epitopes (Phillips, R. E. et al., Nature 1991. 354: 453) and are subject to immune-mediated positive selection (Price, D. A. et al., Proc. Natl. Acad. Sci. USA 1997. 94: 1890). We studied the effects of naturally occurring mutations in the HIV-1 p17 Gag HLA A2 restricted epitope SLYNTVATL on recognition by anti-HIV CTL. Most of these naturally occurring mutants escaped killing by one CTL line and the majority acted as CTL antagonists. We also investigated whether CTL exposed to a strict antagonist peptide restricted by HLA A2 were unresponsive when exposed to targets presenting the wild-type sequence. The results show that antagonism of anti-HIV CTL killing requires the simultaneous presence of agonist and antagonist peptide. We found no evidence that CTL exposed to an antagonist received a functionally negative signal since these CTL retained an unimpaired capacity to lyse targets bearing wild-type peptide.

Original publication

DOI

10.1002/eji.1830270929

Type

Journal article

Journal

Eur J Immunol

Publication Date

09/1997

Volume

27

Pages

2323 - 2329

Keywords

Antigen-Presenting Cells, Clonal Anergy, Cytotoxicity, Immunologic, Gene Products, gag, HIV Antigens, HIV Infections, HIV-1, HLA-A2 Antigen, Humans, Immunity, Cellular, Ligands, Peptides, Structure-Activity Relationship, T-Lymphocytes, Cytotoxic, Viral Proteins, gag Gene Products, Human Immunodeficiency Virus