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Tick saliva (or salivary gland extract) potentiates the transmission of Thogoto (THO) virus to uninfected ticks feeding on a non-viraemic guinea-pig. This phenomenon has been named saliva activated transmission (SAT). To investigate the potential of different haematophagous arthropods to mediate SAT, guinea-pigs were infested with uninfected R.appendiculatus Neumann nymphs and inoculated with THO virus and salivary gland extract (SGE) derived from a range of ixodid (metastriate and prostriate) or argasid ticks, or mosquitoes; control guinea-pigs were inoculated with virus alone. Enhancement of THO virus transmission was observed only when SGE was derived from metastriate ticks. Comparison with the vector potential of these various arthropod species revealed that enhancement of THO virus transmission was specific for ticks which were competent vectors of the virus. The data indicate a correlation between vector competence and the ability of haematophagous arthropods to mediate SAT of THO virus.

Type

Journal article

Journal

Med Vet Entomol

Publication Date

07/1992

Volume

6

Pages

261 - 265

Keywords

Aedes, Animals, Anopheles, Arachnid Vectors, Cell Line, Cricetinae, Female, Nymph, Orthomyxoviridae, Orthomyxoviridae Infections, Saliva, Ticks, Vero Cells, Viremia, Virus Replication