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Thymocytes adoptively transferred into syngeneic irradiated recipients can be primed with antigen (KLH) to generate two types of helper function termed 'specific' and 'non-specific'. Low doses of KLH given without adjuvant generate high levels of non-specific compared to 'specific' helper T cells. Large doses of KLH given in adjuvant (FCA) generate high levels of both types of helper T cell. Explantations for this observation are discussed.


Journal article



Publication Date





721 - 725


Animals, Antibody Specificity, Antigen-Antibody Reactions, Antigens, B-Lymphocytes, Lymphocyte Cooperation, Mice, Mice, Inbred CBA, Radiation Effects, T-Lymphocytes, Transplantation, Isogeneic