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The immune system is naturally unresponsive to 'self' antigens. Improved knowledge of mechanisms underlying self tolerance is giving rise to a new generation of immunosuppressive agents, that can exploit these mechanisms and so reduce the nature and level of medication that needs to be given long-term to control diseases where the immune system does harm.


Journal article


Curr Opin Pharmacol

Publication Date





392 - 397


Animals, Antibodies, Monoclonal, Antigens, Surface, Chemotaxis, Leukocyte, Humans, Immune Tolerance, Immunity, Maternally-Acquired, Organ Transplantation, T-Lymphocytes