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HIV-specific Elispot responses were investigated in 57 antiretroviral therapy-naive children, of median age 9.9 years. CD8(+) T-cell responses were detected in 96% children; Nef was the immunodominant protein. Responses broadened over time, but there was no association between magnitude, breadth or specificity of response and viraemia. Gag-specific CD4(+) T-cell responses, detectable in 26% children, correlated inversely with viraemia (R = -0.43, P < 0.001), suggesting that preservation of this cell population may be an important goal of therapeutic/vaccine strategies.

Original publication

DOI

10.1097/QAD.0b013e3283478575

Type

Journal article

Journal

AIDS

Publication Date

19/06/2011

Volume

25

Pages

1329 - 1331

Keywords

Adolescent, CD4-Positive T-Lymphocytes, Child, Child, Preschool, Female, Genes, gag, HIV Infections, HIV-1, Humans, Male, Viral Load