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The relation between maternal anti-D concentrations, measured against the British working standard, and outcome of rhesus-sensitised pregnancies was studied. There is a clear relation between increasing anti-D concentrations and the chance of a severely affected baby. Of those pregnancies (78) where serial anti-D concentrations remained below 4 IU/ml, no baby had a cord haemoglobin below 10 g/dl and three had exchange transfusions. In contrast, of those mothers (106) with anti-D concentrations above 4 IU/ml, 23 had babies with a cord haemoglobin below 10 g/dl and 79 babies had exchange transfusions. It is suggested that those pregnancies where anti-D concentrations remain below 4 IU/ml represent a relatively safe group in which amniocentesis may be avoided.

Original publication




Journal article


Br Med J (Clin Res Ed)

Publication Date





327 - 329


Bilirubin, Erythroblastosis, Fetal, Exchange Transfusion, Whole Blood, Female, Fetal Blood, Hemoglobins, Humans, Infant, Newborn, Isoantibodies, Pregnancy, Prognosis, Rh-Hr Blood-Group System, Rho(D) Immune Globulin