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<p>Biallelic <i>Vhl</i> inactivation entrains early cell-specific transcriptomic changes in RTE cells. <b>A,</b> Density plot depicting UMAP distribution of tdTomato-negative and -positive cells from kidneys of Control and KO mice harvested early after recombination. <b>B,</b> Left, UMAP plot depicting cells from Control and KO mice harvested early after recombination colored by UMAP clusters. Right, proportion of cells from each condition belonging to any cluster. <b>C,</b> Scatter plot depicting frequency of expression in tdTomato-negative (top) or tdTomato-positive (bottom) cells from KO mice against log<sub>2</sub>-fold change (log<sub>2</sub>FC) between cells from KO versus Control mice for all genes at the early time point. Orange, significantly regulated genes. Genes explicitly mentioned in the main text are labeled. <b>D,</b> Scatter plot depicting log<sub>2</sub>-fold change between tdTomato-positive cells from KO versus Control for genes significantly regulated in every renal cell identity. Blue, names of HIF target genes. <b>E,</b> PCA of gene expression changes early after <i>Vhl</i> inactivation in different renal cell identities. <b>A–E,</b> scRNA-seq data are shown for <i>n</i> = 3F, 1M for Control negative; <i>n</i> = 3F, 1M mice for Control positive samples; <i>n</i> = 2F, 1M mice for KO negative samples; <i>n</i> = 2F, 2M mice for KO-positive samples.</p>

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