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Significant insight has been gained into constraints on the sensitivity and specificity of staining with class I tetramers. The function of the populations that are defined varies with the clinical situation. Insight has also been gained into the determinants of the CD8(+) T cell response during primary and chronic HIV infection. Human class II tetramers have been synthesised but their role in defining CD4(+) T cell function in HIV infection remains to be determined.


Journal article


Curr Opin Immunol

Publication Date





370 - 374


Animals, Anti-HIV Agents, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Drug Therapy, Combination, Fluorescent Dyes, HIV, HIV Antigens, HIV Infections, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Humans, Staining and Labeling