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Monoclonal antibodies (MoAbs) have the potential to facilitate the induction of transplantation tolerance. Realization of this potential requires both a better understanding of the cellular events concerned with rejection and tolerance, and a more detailed approach to improving antibodies for therapy. This report reviews work in our laboratory directed toward these goals.


Journal article


Am J Kidney Dis

Publication Date





154 - 158


Animals, Antibodies, Monoclonal, Graft Rejection, Humans, Immune Tolerance, Mice, Rats, T-Lymphocytes, Time Factors, Transplantation, Transplantation Immunology