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Less than five years ago it was reported that cell surface molecules at the contact site between CD4 T cells and antigen-presenting cells redistribute into distinct patterns, forming an organized interface termed the immunological synapse. More recently, similar reorganized interfaces have been observed with CD8 T cells and NK cells, suggesting that they may be a common feature of lymphocyte activation. Although there has been some advance in our understanding of the mechanisms underlying this redistribution, its purpose remains unclear and controversial.


Journal article


Curr Opin Immunol

Publication Date





293 - 298


Animals, Antigen-Presenting Cells, Antigens, CD, Cell Polarity, Humans, Leukosialin, Receptors, Antigen, T-Cell, Sialoglycoproteins, Synapses, T-Lymphocytes