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There is increasing evidence that NF-kappaB is a major, if not the major transcription factor regulating inflammation and immunity. While this implies that blocking NF-kappaB might be therapeutically beneficial, it raises clear questions regarding the balance between efficacy and safety. In this brief review we discuss the effects of NF-kappaB blockade in rheumatoid arthritis, inflammation and immunity, and consider possible therapeutic targets within the NF-kappaB family.

Original publication




Journal article


Ann Rheum Dis

Publication Date



61 Suppl 2


ii13 - ii18


Adenoviridae, Antigen Presentation, Arthritis, Rheumatoid, Cell Culture Techniques, Dendritic Cells, Genetic Vectors, Humans, I-kappa B Proteins, Immunity, Cellular, Lymphocyte Culture Test, Mixed, NF-kappa B, Synovial Membrane