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The landmark paper by Hirose et al. (Hirose, K., Kadowaki, S., Tanabe, M., Takeshima, H., Iino, M., Science 284:1527-1530, 1999) presented experimental investigations to show that not only can calcium upregulate IP(3), but that it can also have an inhibitory effect on IP(3). In this paper, we present a preliminary model, which is consistent with these experiments. This model includes positive and negative feedback between calcium and IP(3) and is able to reproduce more precisely the data presented in Hirose et al. (Hirose, K., Kadowaki, S., Tanabe, M., Takeshima, H., Iino, M., Science 284:1527-1530, 1999). In the second part of the paper, the intracellular and intercellular calcium movement in Madin-Darby canine kidney epithelial cells is investigated. With the aid of the model we are able to identify the aspects of IP(3) and calcium signalling, which should be studied further experimentally before refining the model.

Original publication

DOI

10.1007/s11538-006-9064-1

Type

Journal article

Journal

Bull Math Biol

Publication Date

11/2006

Volume

68

Pages

2027 - 2051

Keywords

Adenosine Triphosphate, Animals, Calcium, Cell Line, Dogs, Epithelial Cells, Inositol 1,4,5-Trisphosphate, Kidney, Models, Biological, Signal Transduction