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Hepatitis C virus (HCV) readily causes a persistent infection, although some individuals spontaneously control infection. 'Successful' immune responses appear to be multi-specific and sustained-including a major role for CD4(+)T cells. Some antiviral CD8(+)T cells show reduced capacity to secrete antiviral cytokines either temporarily ('stunning') or in the long term ('stunting'). The co-ordination of multiple immune effector functions may be required to gain control of HCV.


Journal article


Microbes Infect

Publication Date





57 - 65


Animals, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Hepacivirus, Hepatitis C, Humans, Killer Cells, Natural, Mice, Receptors, Antigen, T-Cell, alpha-beta