Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Voltage-gated potassium channel antibody (VGKC-Ab)-associated limbic encephalitis (LE) is a recently described syndrome that broadens the spectrum of immunotherapy-responsive central nervous system disorders. Limbic encephalitis is typically characterised by a sub-acute onset of disorientation, amnesia and seizures, but the clinical spectrum is not yet fully defined and the syndrome could be under-diagnosed. We here describe the clinical profile of four patients with VGKC-Ab-associated LE who had intermittent, episodic hypothermia. One of the patients also described a prodrome of severe neuropathic pain preceding the development of limbic symptoms. Both of these novel symptoms responded well to immunosuppressive therapy, with concurrent amelioration of amnesia/seizures.

Original publication




Journal article


J Neurol Neurosurg Psychiatry

Publication Date





202 - 204


Aged, Atrophy, Autoantibodies, Azathioprine, Cyclosporine, Dominance, Cerebral, Epilepsy, Temporal Lobe, Female, Hippocampus, Humans, Hypothalamus, Hypothermia, Immunization, Passive, Immunosuppressive Agents, Limbic Encephalitis, Low Back Pain, Magnetic Resonance Imaging, Male, Middle Aged, Plasma Exchange, Potassium Channels, Voltage-Gated, Prednisolone, Recurrence, Retreatment, Temporal Lobe, Thymoma, Thymus Neoplasms