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High-resolution structures have given an extremely detailed view of aspects of ribosomes, including some near-functional states. Here, we review the importance of cryo-electron microscopy, among other techniques, in giving an understanding of the higher dynamics of the ribosome accompanying active recruitment of mRNA to the small subunit and translocation of tRNAs. Recent data show that careful use of a variety of different techniques is necessary for a proper understanding of the basis of function in systems such as the ribosome.

Original publication

DOI

10.1042/BST0360677

Type

Journal article

Journal

Biochem Soc Trans

Publication Date

08/2008

Volume

36

Pages

677 - 683

Keywords

Ligands, Protein Binding, Protein Biosynthesis, Ribosomes, Transcription, Genetic