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We investigated whether therapeutic vaccination in highly active antiretroviral therapy (HAART)-treated patients with a modified vaccinia virus Ankara-vectored HIV-1 vaccine, with or without therapy interruption, induced the production of interleukin (IL)-10. Plasma IL-10 levels were not significantly increased postvaccination, but increased in parallel with viraemia in patients who interrupted therapy. Surprisingly, IL-10 blockade augmented HIV-specific T cell proliferative responses in HAART-suppressed patients but had no effect once virological control was lost. Modulation of IL-10 might enhance vaccine-induced immune responses.

Original publication

DOI

10.1097/QAD.0b013e328331a424

Type

Journal article

Journal

AIDS

Publication Date

23/10/2009

Volume

23

Pages

2226 - 2230

Keywords

AIDS Vaccines, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, HIV Infections, HIV-1, Humans, Interleukin-10, RNA, Viral, Viral Load