Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Analogues of the naturally occurring cyclic hydroxamate dealanylalahopcin, which is an inhibitor of procollagen prolyl-4-hydroxylase, were synthesised and shown to be inhibitors of the human hypoxia-inducible factor prolyl hydroxylases.


Journal article


Bioorg Med Chem Lett

Publication Date





1451 - 1454


Aminobutyrates, Animals, Autoradiography, Binding Sites, Enzyme Inhibitors, Humans, Hypoxia-Inducible Factor 1, alpha Subunit, Iron, Isoenzymes, Procollagen-Proline Dioxygenase, Transcription Factors, Tumor Suppressor Proteins