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Acidic pH is a common characteristic of human tumours. It has a significant impact on tumour progression and response to therapies. In this paper, we develop a simple model of three-dimensional tumour growth to examine the role of acidosis in the interaction between normal and tumour cell populations. Both vascular and avascular tumour dynamics are investigated, and a number of different behaviours are observed. Whilst an avascular tumour always proceeds to a benign steady state, a vascular tumour may display either benign or invasive dynamics, depending on the value of a critical parameter. Analysis of the model allows us to assess novel therapies directed towards changing the level of acidity within the tumour.

Original publication

DOI

10.1016/j.jtbi.2005.02.001

Type

Journal article

Journal

J Theor Biol

Publication Date

21/08/2005

Volume

235

Pages

476 - 484

Keywords

Cell Proliferation, Disease Progression, Humans, Hydrogen-Ion Concentration, Models, Biological, Necrosis, Neoplasm Invasiveness, Neoplasms, Neovascularization, Pathologic