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Histamine is an important mediator of early and late inflammatory responses. Here we asked whether scavenging of endogenous histamine by the arthropod-derived histamine binding protein EV131 diminishes acute respiratory distress syndrome (ARDS) induced by inhaled endotoxin. We demonstrate that EV131 (360 microg given intranasally) reduced endotoxin-induced bronchoconstriction and recruitment of neutrophils. Furthermore, EV131 administration diminished TNF-alpha and protein leak in the bronchoalveolar lavage fluid. The data suggest that histamine attenuates endotoxin-induced bronchoconstriction and neutrophil recruitment. Therefore, scavenging of histamine by EV131 may represent a novel therapeutic strategy in ARDS.

Original publication

DOI

10.1196/annals.1352.034

Type

Journal article

Journal

Ann N Y Acad Sci

Publication Date

11/2005

Volume

1056

Pages

197 - 205

Keywords

Airway Resistance, Animals, Endotoxins, Humans, Mice, Mice, Inbred C57BL, Peroxidase, Receptors, Histamine, Respiratory Distress Syndrome, Adult