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CAMPATH-1H is a humanised mAb directed against lymphocytes. This mAb has been used to treat patients with rheumatoid arthritis. Clinical improvement with reduction in the Ritchie index and joint score has lasted for up to 8 months in some patients. A profound and prolonged lymphopaenia is induced by the mAb, with CD4+ numbers remaining suppressed for up to one year.


Conference paper

Publication Date



11 Suppl 8


S165 - S167


Animals, Antibodies, Monoclonal, Antigens, CD, Antigens, Neoplasm, Arthritis, Rheumatoid, CD52 Antigen, Glycoproteins, Humans, Leukocyte Count, Lymphocyte Depletion, Lymphocytes, Recombinant Fusion Proteins