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After many years of research, somitogenesis is still one of the major unresolved problems in developmental biology. Recent experimental findings show a novel type of pattern formation in which a signal sweeps along the presomitic mesoderm and narrows simultaneously as a new somite is formed. The signal then residues in the posterior half of the new somite, and another wave begins to sweep up from the caudal end. This behaviour is not easily explained by the existing theoretical models. We present a new model for somitogenesis that can account for this behaviour and is consistent with previous experimental observations.

Original publication

DOI

10.1002/(SICI)1097-0177(200004)217:4<415::AID-DVDY8>3.0.CO;2-3

Type

Journal article

Journal

Dev Dyn

Publication Date

04/2000

Volume

217

Pages

415 - 420

Keywords

Animals, Biological Clocks, Cleavage Stage, Ovum, Mice, Models, Biological, Somites