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HLA-E binds specifically to MHC class Ia leader peptides in a TAP (transporter associated with antigen processing)-dependent manner. It interacts with CD94/NKG2A receptors on natural killer cells and this inhibits natural killer cell lysis of the cell displaying HLA-E. The crystal structure of HLA-E demonstrates that the specificity of leader peptide binding is a structurally defined intrinsic property of HLA-E.


Journal article


Microbes Infect

Publication Date





371 - 380


Animals, Antigen Presentation, Antigens, CD, Cytotoxicity, Immunologic, HLA Antigens, Histocompatibility Antigens Class I, Killer Cells, Natural, Lectins, C-Type, Membrane Glycoproteins, Mice, Models, Immunological, NK Cell Lectin-Like Receptor Subfamily C, NK Cell Lectin-Like Receptor Subfamily D, Protein Sorting Signals, Receptors, Immunologic, Receptors, Natural Killer Cell