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Matrix orientation plays a crucial role in determining the severity of scar tissue after dermal wounding. We present a model framework which allows us to examine the interaction of many of the factors involved in orientation and alignment. Within this framework, cells are considered as discrete objects, while the matrix is modelled as a continuum. Using numerical simulations, we investigate the effect on alignment of changing cell properties and of varying cell interactions with collagen and fibrin.

Original publication

DOI

10.1006/jtbi.1999.0971

Type

Journal article

Journal

J Theor Biol

Publication Date

21/08/1999

Volume

199

Pages

449 - 471

Keywords

Animals, Collagen, Extracellular Matrix, Fibrin, Fibroblasts, Models, Biological, Regeneration, Wound Healing