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Clostridium difficile infection (CDI) is a leading cause of antibiotic-associated diarrhoea and is endemic in hospitals, hindering the identification of sources and routes of transmission based on shared time and space alone. This may compromise rational control despite costly prevention strategies. This study aimed to investigate ward-based transmission of C. difficile, by subdividing outbreaks into distinct lineages defined by multi-locus sequence typing (MLST).

Original publication

DOI

10.1371/journal.pmed.1001172

Type

Journal article

Journal

PLoS Med

Publication Date

02/2012

Volume

9

Addresses

National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom. asw@ctu.mrc.ac.uk

Keywords

Anti-Bacterial Agents, Base Sequence, Clostridium difficile, Cross Infection, Diarrhea, Endemic Diseases, Enterocolitis, Pseudomembranous, Gastrointestinal Tract, Hospital Units, Hospitalization, Humans, Infection Control, Multilocus Sequence Typing