Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Understanding the regulation of immune responses is central for control of autoimmune and infectious disease. In murine models of autoimmunity and chronic inflammatory disease, potent regulatory T lymphocytes have recently been characterized. Despite an explosion of interest in these cells, their relevance to human disease has been uncertain. In a longitudinal study of malaria sporozoite infection via the natural route, we provide evidence that regulatory T cells have modifying effects on blood-stage infection in vivo in humans. Cells with the characteristics of regulatory T cells are rapidly induced following blood-stage infection and are associated with a burst of TGF-beta production, decreased proinflammatory cytokine production, and decreased antigen-specific immune responses. Both the production of TGF-beta and the presence of CD4+CD25+FOXP3+ regulatory T cells are associated with higher rates of parasite growth in vivo. P. falciparum-mediated induction of regulatory T cells may represent a parasite-specific virulence factor.

Original publication

DOI

10.1016/j.immuni.2005.08.006

Type

Journal article

Journal

Immunity

Publication Date

09/2005

Volume

23

Pages

287 - 296

Keywords

Animals, CD4 Antigens, Clinical Trials as Topic, DNA-Binding Proteins, Forkhead Transcription Factors, Humans, Malaria, Falciparum, Plasmodium falciparum, Receptors, Interleukin-2, T-Lymphocytes, Transforming Growth Factor beta, Up-Regulation