Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about innate immunity and host-pathogen interactions. Here, we review current research in the field, encompassing all layers of defence from the role of the microbiota to systemic immune activation, and attempt to speculate on future directions and open questions.

Original publication

DOI

10.1098/rsob.120075

Type

Journal article

Journal

Open Biol

Publication Date

05/2012

Volume

2

Keywords

Drosophila, host defence, innate immunity, Animals, Antimicrobial Cationic Peptides, Bacteria, Drosophila Proteins, Drosophila melanogaster, Fat Body, Hemocytes, Hemolymph, Immunity, Innate, Immunity, Mucosal, Intestines, Larva, Melanins, Microbial Consortia, Models, Immunological, Phagocytosis, Reactive Oxygen Species, Receptors, Immunologic, Serratia marcescens, Signal Transduction, Yeasts