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Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about innate immunity and host-pathogen interactions. Here, we review current research in the field, encompassing all layers of defence from the role of the microbiota to systemic immune activation, and attempt to speculate on future directions and open questions.

Original publication




Journal article


Open Biol

Publication Date





Drosophila, host defence, innate immunity, Animals, Antimicrobial Cationic Peptides, Bacteria, Drosophila Proteins, Drosophila melanogaster, Fat Body, Hemocytes, Hemolymph, Immunity, Innate, Immunity, Mucosal, Intestines, Larva, Melanins, Microbial Consortia, Models, Immunological, Phagocytosis, Reactive Oxygen Species, Receptors, Immunologic, Serratia marcescens, Signal Transduction, Yeasts