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The major histocompatibility complex class I molecule HLA-A2.1 presents the influenza A virus matrix peptide 57-68 to cytotoxic T lymphocytes in all individuals with this common HLA type and is among the most thoroughly studied immune responses in humans. We have studied the T-cell receptor (TCR) heterogeneity of T cells specific for HLA-A2 and influenza A matrix peptide using the polymerase chain reaction. The usage of V alpha and V beta sequences seen on these T cells is remarkably conserved as are certain junctional sequences associated with alpha and beta chains. Furthermore, two unrelated HLA-A2 individuals have a similar pattern of TCR usage, implying that this is a predominant response in HLA-A2 populations. Analysis in one individual showed that the conserved TCR V alpha and V beta genes are minor members of the peripheral blood TCR repertoire. The sequences provide important information on the TCR necessary for the final structural analysis of this ternary complex.

Original publication




Journal article


Proc Natl Acad Sci U S A

Publication Date





8987 - 8990


Amino Acid Sequence, Base Sequence, Cell Line, Cytotoxicity, Immunologic, HLA-A2 Antigen, Humans, Immunoglobulin Joining Region, Immunoglobulin Variable Region, Influenza A virus, Molecular Sequence Data, Oligonucleotides, Polymerase Chain Reaction, Receptors, Antigen, T-Cell, Receptors, Antigen, T-Cell, alpha-beta, T-Lymphocytes, T-Lymphocytes, Cytotoxic, Viral Matrix Proteins