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Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.

Original publication




Journal article


Nat Med

Publication Date





819 - 821


Adenoviridae, Animals, Genetic Vectors, Immunoglobulin G, Malaria, Malaria Vaccines, Mice, Mice, Inbred BALB C, Plasmodium falciparum, Plasmodium yoelii, Poxviridae, T-Lymphocytes, Vaccines, Vaccines, Subunit, Viral Vaccines