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A patient with thymoma-associated neuromyotonia and voltage-gated potassium channel (Kv1.2 and Kv1.6) antibodies by immunoprecipitation and rat brain immunolabeling was treated successfully with immunoadsorption and cyclophosphamide. Curiously, glutamic acid decarboxylase antibodies, absent at onset, appeared later. Stiff-person syndrome was absent, but fast blink reflex recovery suggested enhanced brainstem excitability. The range of antibodies produced in thymoma-associated neuromyotonia is richer, and the timing of antibody appearance more complex, than previously suspected.

Original publication




Journal article



Publication Date





1290 - 1293


Adult, Animals, Autoantibodies, Autoimmune Diseases of the Nervous System, Blinking, Brain Stem, Cyclophosphamide, Glutamate Decarboxylase, Humans, Immunosorbent Techniques, Immunosuppressive Agents, Isaacs Syndrome, Kv1.2 Potassium Channel, Kv1.6 Potassium Channel, Male, Potassium Channels, Voltage-Gated, Rats, Reflex, Abnormal, Thymoma, Thymus Neoplasms, Treatment Outcome, gamma-Aminobutyric Acid