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The Ly and Ia phenotypes of T lymphocytes involved in the in vitro generation of helper and suppressor cells were identified. The precursors of both cells are found in adult thymectomized spleen. Helper precursors are Ly-1+2-3-Ia-, while suppressor precursors are Ly-1-2+3+Ia-, although the suppressor effector is Ia+. In both cases a second 'amplifier' cell is required for differentiation of precursors to occur. This cell is found in anti-lymphocyte serum-treated spleen and has the phenotype Ly-1+2+3+Ia-.

Original publication




Journal article


J Exp Med

Publication Date





793 - 801


Animals, Antilymphocyte Serum, Cell Differentiation, Cell Membrane, Epitopes, Immunoglobulin M, Immunosuppression, Isoantigens, Mice, Phenotype, Spleen, T-Lymphocytes