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Research in the past few years has documented significant advances in our understanding of the CD40-CD40 ligand (CD154) system in diverse immune functions. This system influences many T cell mediated inflammatory immune responses and effector functions, unmasking a previously unexpected role for CD40-CD154 in cell mediated immunity. Manipulation of CD154 in animal models of infection by the use of CD154-deficient mice or anti-CD154 antibodies has shown the importance of this system in the initiation of the inflammatory response, in the activation of antigen-presenting cells and in resistance to infections.


Journal article


Curr Opin Immunol

Publication Date





491 - 497


Animals, Antigen Presentation, Borrelia Infections, CD40 Antigens, CD40 Ligand, Humans, Infection, Leishmaniasis, Listeriosis, Macrophage Activation, Membrane Glycoproteins, Mice, Nematode Infections, Pneumocystis Infections, T-Lymphocyte Subsets