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We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD.

Original publication




Journal article


Am J Gastroenterol

Publication Date





1770 - 1776


Clinical Trials as Topic, Concept Formation, Consensus, Crohn Disease, Disease Progression, Health Knowledge, Attitudes, Practice, Humans, Inflammatory Bowel Diseases, International Cooperation, Severity of Illness Index, Time Factors