Development of the Paris definition of early Crohn's disease for disease-modification trials: results of an international expert opinion process.
Peyrin-Biroulet L., Billioud V., D'Haens G., Panaccione R., Feagan B., Panés J., Danese S., Schreiber S., Ogata H., Hibi T., Higgins PDR., Beaugerie L., Chowers Y., Louis E., Steinwurz F., Reinisch W., Rutgeerts P., Colombel J-F., Travis S., Sandborn WJ.
We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD.