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The discovery that tissue plasminogen activator can promote neuronal degeneration has uncovered a novel pathway leading to neuronal cell death and raises important issues concerning the use of tissue plasminogen activator as a thrombolytic therapy for stroke.


Journal article


Curr Biol

Publication Date





R274 - R277


Animals, Brain Ischemia, Cell Death, Humans, Mice, Microglia, Neurons, Thrombolytic Therapy, Tissue Plasminogen Activator