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The somitogenesis clock regulates the periodicity with which somites form in the posterior pre-somitic mesoderm. Whilst cell heterogeneity results in noisy oscillation rates amongst constituent cells, synchrony within the population is maintained as oscillators are entrained via juxtracine signalling mechanisms. Here we consider a population of phase-coupled oscillators and investigate how biologically motivated perturbations to the entrained state can perturb synchrony within the population. We find that the ratio of mitosis length to clock period can influence levels of desynchronisation. Moreover, we observe that random cell movement, and hence change of local neighbourhoods, increases synchronisation. © Springer-Verlag Berlin Heidelberg 2013.

Original publication

DOI

10.1007/978-3-642-20164-6_9

Type

Journal article

Journal

Springer Proceedings in Mathematics

Publication Date

22/04/2013

Volume

15

Pages

95 - 105