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Truncated constructs of 64P (64TRPs), a secreted cement protein from salivary glands of the tick Rhipicephalus appendiculatus, provided cross-protection against Rhipicephalus sanguineus and Ixodes ricinus, apparently by targeting antigens in the midgut and salivary glands of adults and nymphs, causing mortality. Tick feeding on 64TRP-immunised animals stimulated local inflammatory immune responses (involving basophils, eosinophils, lymphocytes, mast cells, macrophages and dendritic-like cells) that boosted the immune status of vaccinated animals. The vaccine trial results, and antigenic cross-reactivity of 64TRPs with R. sanguineus, I. ricinus, Amblyomma variegatum and Boophilus microplus, indicate the potential of 64TRPs as a broad-spectrum anti-tick vaccine.

Original publication

DOI

10.1016/j.vaccine.2005.03.041

Type

Journal article

Journal

Vaccine

Publication Date

29/07/2005

Volume

23

Pages

4329 - 4341

Keywords

Animals, Antigens, Cricetinae, Cross Reactions, Guinea Pigs, Immunization, Skin, Tick Infestations, Ticks, Vaccines, Synthetic