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Salivary gland extract (SGE) of four horsefly species (Hybomitra bimaculata Macquart, Hybomitra ciureai Séguy, Tabanus bromius L., Tabanus glaucopis Meigen) and one deerfly species (Chrysops relictus Meigen) (Diptera: Tabanidae) were shown to contain vasodilatory activity. Aliquots equivalent to 1, 5 and 10 pairs of salivary glands (SG) relaxed rat femoral artery (with intact endothelium) pre-constricted with phenylephrine. Vasodilatory activity was dose-dependent. SGE of one horsefly species (Haematopota pluvialis L.) did not induce relaxation. The kinetics of vasodilation induced by SGE of four horsefly species differed from the deerfly. These results indicate that tabanid species may produce more than one type of vasodilator to aid blood feeding.

Type

Journal article

Journal

Med Vet Entomol

Publication Date

12/2003

Volume

17

Pages

395 - 402

Keywords

Animals, Blood Flow Velocity, Diptera, Dose-Response Relationship, Drug, Feeding Behavior, Female, Femoral Artery, Host-Parasite Interactions, Kinetics, Male, Rats, Rats, Wistar, Salivary Glands, Species Specificity, Tissue Extracts, Vasodilation, Vasodilator Agents