Myeloid leukemia in children 4 years or older with Down syndrome often lacks GATA1 mutation and cytogenetics and risk of relapse are more akin to sporadic AML.

Hasle H.; Abrahamsson J.; Arola M.; Karow A.; O'Marcaigh A.; Reinhardt D.; Webb DKH.; van Wering E.; Zeller B.; Zwaan CM.; Vyas P.

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Myeloid leukemia in children 4 years or older with Down syndrome often lacks GATA1 mutation and cytogenetics and risk of relapse are more akin to sporadic AML.

Hasle H., Abrahamsson J., Arola M., Karow A., O'Marcaigh A., Reinhardt D., Webb DKH., van Wering E., Zeller B., Zwaan CM., Vyas P.

Original publication

DOI

10.1038/sj.leu.2405060

Type

Journal article

Journal

Leukemia

Publication Date

07/2008

Volume

22

Pages

1428 - 1430

Keywords

Child, Child, Preschool, Chromosome Aberrations, Down Syndrome, GATA1 Transcription Factor, Humans, Leukemia, Myeloid, Acute, Mutation, Recurrence, Risk