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Evidence is presented which suggests that T cell-dependent nonspecific factor (NSF) cannot be the sole mediator of 'co-operation' for all types of thymus-dependent antibody response. NSF can replace the requirement for T cells in responses to hapten conjugated to particulate carriers, but cannot do so in responses to hapten conjugates of soluble thymus-dependent carriers.


Journal article



Publication Date





497 - 507


Animals, Antibodies, Antibody Formation, Antibody Specificity, Antibody-Producing Cells, Antigen-Antibody Reactions, Antigens, Carrier Proteins, Cells, Cultured, Erythrocytes, Freund's Adjuvant, Haptens, Hemolytic Plaque Technique, Immunity, Immunization, Mice, Mice, Inbred CBA, Protein Binding, Sheep, T-Lymphocytes