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Immunological and neural synapses share properties such as the synaptic cleft, adhesion molecules, stability, and polarity. However, the mismatch in scale has limited the utility of these comparisons. The discovery of phosphatase micro-exclusion from signaling elements in immunological synapses and innate phagocytic synapses define a common functional unit at a common sub-micron scale across synapse types. Bundling of information from multiple antigen receptor microclusters by an immunological synapse has parallels to bundling of multiple synaptic inputs into a single axonal output by neurons, allowing integration and coincidence detection. Bonafide neuroimmune synapses control the inflammatory reflex. A better understanding of the shared mechanisms between immunological and neural synapses could aid in the development of new therapeutic modalities for immunological, neurological, and neuroimmunological disorders alike.

Original publication





Publication Date





1149 - 1155


Animals, Biological Evolution, Dendritic Cells, Humans, Immunologic Capping, Immunological Synapses, Inflammation, Leukocyte Common Antigens, Lymphocyte Cooperation, Models, Biological, Models, Immunological, Neuroimmunomodulation, Neurons, Phagocytosis, Phosphorylation, Protein Processing, Post-Translational, Receptors, Immunologic, Signal Transduction, Synapses, Vagus Nerve