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Protein kinase C (PKC)-θ regulates conventional effector T (Teff) cell function. Since this initial finding, it has become clear that the role of PKC-θ in T cells is complex. PKC-θ plays a central role in Teff cell activation and survival, and negatively regulates stability of the immunological synapse (IS). Recent studies demonstrated that PKC-θ is required for the development of natural CD4(+)Foxp3(+) regulatory T (Treg) cells, and mediates negative regulation of Treg cell function. Here, we examine the role of PKC-θ in the IS, evidence for its distinct localization in Treg cells and the therapeutic implications of inhibiting PKC-θ in Teff cells, to reduce effector function, and in Treg cells, to increase suppressor function, for the prevention and treatment of autoimmune and alloimmune disease states.

Original publication




Journal article


Trends Immunol

Publication Date





358 - 363


Animals, Autoimmune Diseases, Humans, Immunological Synapses, Immunotherapy, Lymphocyte Activation, Molecular Targeted Therapy, Protein Kinase C, Receptor-CD3 Complex, Antigen, T-Cell, Signal Transduction, T-Lymphocyte Subsets, T-Lymphocytes, Regulatory