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The immunological synapse has been an area of very active scientific interest over the last decade. Surprisingly, much about the synapse remains unknown or is controversial. Here we review some of these current issues in the field: how the synapse is defined, its potential role in T-cell function, and our current understanding about how the synapse is formed.

Original publication




Journal article


Cold Spring Harb Perspect Biol

Publication Date





Animals, Cell Movement, Cell Polarity, Humans, Immunological Synapses, Lymphocyte Activation, Mice, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes