Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Just over two years ago the newest member of the interleukin family of cytokines, IL-18, was molecularly cloned. IL-18 was originally identified as a result of its ability to induce interferon gamma production, however with the advent of its cloning and the production of recombinant protein a number of other biological actions have since been identified. Recently the receptor for IL-18 was also characterised. Due to the structural and biological properties shared between IL-18 and IL-1 and their respective receptors, questions relating to IL-18 activities are being answered at a rapid pace. This article addresses the biology of IL-18 in both disease and non-disease states.


Journal article


Cytokine Growth Factor Rev

Publication Date





109 - 116


Amino Acid Sequence, Animals, Autoimmunity, Diabetes Mellitus, Type 1, Gene Expression, Humans, Interleukin-1, Interleukin-18, Interleukin-18 Receptor alpha Subunit, Molecular Sequence Data, Neoplasms, Experimental, Osteoclasts, Receptors, Interleukin, Receptors, Interleukin-18, T-Lymphocytes