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Isoelectric focusing gel electrophoresis was used to look for variant HLA molecules in five patients with HLA-B27 negative ankylosing spondylitis (AS). The isoelectric points of the HLA-A and B antigens from these patients and HLA paired controls were identical. This implies that the HLA-A and B antigens from the patients with AS and the controls are similar. Gene conversion of a nucleotide sequence from a B27 positive gene is thus unlikely to be the explanation for the existence of AS in patients who are HLA-B27 negative by alloantisera typing.

Original publication




Journal article


Ann Rheum Dis

Publication Date





1001 - 1003


Female, Gene Conversion, HLA-A Antigens, HLA-B Antigens, HLA-B27 Antigen, Humans, Isoelectric Focusing, Male, Spondylitis, Ankylosing