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Haemophilus influenzae type b (Hib) is now recognized as an important pathogen in Asia. To evaluate disease susceptibility, and as a marker of Hib transmission before routine immunization was introduced in Kathmandu, 71 participants aged 7 months-77 years were recruited and 15 cord blood samples were collected for analysis of anti-polyribosylribitol phosphate antibody levels by enzyme-linked immunosorbent assay. Only 20% of children under 5 years old had levels considered protective (>0.15 µg/ml), rising to 83% of 15-54 year-olds. Prior to introduction of Hib vaccine in Kathmandu, the majority of young children were susceptible to disease.

Original publication




Journal article


PLoS One

Publication Date





Adolescent, Adult, Aged, Antibodies, Bacterial, Bacterial Capsules, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Haemophilus Infections, Haemophilus Vaccines, Haemophilus influenzae type b, Host-Pathogen Interactions, Humans, Immunization Programs, Infant, Middle Aged, Nepal, Polysaccharides, Polysaccharides, Bacterial, Seroepidemiologic Studies, Vaccination, Young Adult