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In humans and mice, γδ T cells represent <5% of the total circulating lymphocytes. In contrast, the γδ T cell compartment in ruminants accounts for 15-60% of the total circulating mononuclear lymphocytes. Despite the existence of CD4(+)CD25(high) Foxp3(+) T cells in the bovine system, these are neither anergic nor suppressive. We present evidence showing that bovine γδ T cells are the major regulatory T cell subset in peripheral blood. These γδ T cells spontaneously secrete IL-10 and proliferate in response to IL-10, TGF-β, and contact with APCs. IL-10-expressing γδ T cells inhibit Ag-specific and nonspecific proliferation of CD4(+) and CD8(+) T cells in vitro. APC subsets expressing IL-10 and TFG-β regulate proliferation of γδ T cells producing IL-10. We propose that γδ T cells are a major regulatory T cell population in the bovine system.

Original publication

DOI

10.4049/jimmunol.1303398

Type

Journal article

Journal

J Immunol

Publication Date

01/07/2014

Volume

193

Pages

208 - 222

Keywords

Animals, Antigen-Presenting Cells, Antigens, Cattle, Cell Proliferation, Interleukin-10, Mice, Receptors, Antigen, T-Cell, gamma-delta, T-Lymphocytes, Regulatory, Transforming Growth Factor beta