Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the virion glycome.
Crispin M., Harvey DJ., Bitto D., Halldorsson S., Bonomelli C., Edgeworth M., Scrivens JH., Huiskonen JT., Bowden TA.
Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.