Complementation of H-2-linked Ir genes: Use of helper factor to analyze responses to GLPhe
Baltz M., Maurer PH., Merryman CF., Feldmann M.
Responses to GLPhe5 were generated in vitro, using the GLPhe helper factor. A plaque assay, using GLPhe-coated SRC, was used to measure antibody responses to GLPhe. Mice of different H-2 haplotypes were tested for the ability to produce the GLPhe helper factor or to respond to a known GLPhe helper factor. We report here defects in nonresponder mice of different strains in both the production of helper factor and in the capacity to respond to it. © 1978 Springer-Verlag New York Inc.